Released Lipids Regulate Transient Receptor Potential Channel (TRP)-Dependent Oral Cancer Pain
نویسندگان
چکیده
منابع مشابه
Released lipids regulate Transient Receptor Potential Channel (TRP)-dependent oral cancer pain
BACKGROUND Pain in the head neck area is an early symptom in oral cancer, supporting the hypothesis that cancer cells control the activities of surrounding nociceptors at the site of the tumor. Several reports implicate TRPV1 and TRPA1 in cancer pain, although there is a large gap in knowledge since the mechanisms for tumor-induced activation of these TRP receptors are unknown. Interestingly, T...
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Despite the advances in detection of and therapies for various tumors, high rates of treatment failure and mortality still exist throughout the world. These high rates are mainly due to the powerful capability of tumor cells to proliferate and migrate. Recent studies regarding the transient receptor potential (TRP) have indicated that TRP channels are associated with tumors and that TRP channel...
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ATP and ADP are ancient extra-cellular signalling molecules that in Dictyostelium amoebae cause rapid, transient increases in cytosolic calcium due to an influx through the plasma membrane. This response is independent of hetero-trimeric G-proteins, the putative IP3 receptor IplA and all P2X channels. We show, unexpectedly, that it is abolished in mutants of the polycystin-type transient recept...
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1. Influx of Ca2+, Mg2+ and Na+, and efflux of K+, have central importance for the function and survival of vascular smooth muscle cells, but progress in understanding the influx/efflux pathways has been restricted by a lack of identification of the genes underlying many of the nonvoltage-gated cationic channels. 2. This review highlights evidence suggesting the genes are mammalian homologues o...
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Transient receptor potential (TRP) channels are found among mammals, flies, worms, ciliates, Chlamydomonas, and yeast but are absent in plants. These channels are believed to be tetramers of proteins containing six transmembrane domains (TMs). Their primary structures are diverse with sequence similarities only in some short amino acid sequence motifs mainly within sequences covering TM5, TM6, ...
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ژورنال
عنوان ژورنال: Molecular Pain
سال: 2015
ISSN: 1744-8069,1744-8069
DOI: 10.1186/s12990-015-0016-3